MMP2 and Hepatic fibrosis: Increased MMP-2 expression has been associated with chronic hepatitis, liver fibrosis, alcoholic liver cirrhosis, ischemia and reperfusion injury (IRI), biliary atresia (BA) (progressive fibroinflammatory cholangiopathy of infancy and a leading indication for pediatric liver transplantation) and HCC (epithelial–mesenchymal transition (EMT) and metastasis) (Table 1) [44,45,46,47,48,117].