In another study, Liu et al. explored MMP-1 induction by diethyldithiocarbamate (DDC) controlled by Akt and ERK/miR-222/ETS-1 pathways as a novel mechanism of MMP-1 regulation, suggesting that miR-222 inhibition (resulting in MMP-1 induction) is a potential approach for the treatment of liver fibrosis [128]. Here, MMP1 is linked to Hepatic fibrosis.