In patients with ALD, Prystupa et al. assessed MMP-2 (and MMP-8 and MMP-9) as a potential biomarker and found that MMP-2 was elevated during all the stages in alcoholic liver cirrhosis, while MMP-8 and MMP-9 were only increased in advanced liver cirrhosis (stage C) [48]. This evidence concerns the gene MMP9 and cirrhosis of liver.