MMP1 and Hepatic fibrosis: Recently, Itaba et al. reported that orthotropic transplantation of IC-2 (a derivative of Wnt/β-catenin inhibitor) engineered BMSCs sheets inhibited chronic CCl4-induced liver fibrosis by inducing production of MMP-1 (and MMP-14 and thioredoxin) with subsequent suppression of HSCs activation [127].