Significantly elevated numbers of sEVs (mean 4.95 ×109 per 1 mL of plasma, p = 0.0206) were isolated from the plasma of patients with APS as well as aPL-neg IT (5.88 ×109 per mL, p = 0.0067) compared to 2.64 ×109 isolated sEVs per mL of plasma from HBD (Figure 2A). The gene discussed is FASLG; the disease is autoimmune polyendocrinopathy.