Our study demonstrated the presence of platelet (CD41b and CD42a)-, CD8 lymphocyte-, endothelial cell (CD31)-, leukocyte (CD45)- and antigen presenting cell (HLA-ABC)-derived sEVs in plasma of patients with a history of thrombosis, as well as in HBD. The gene discussed is PTPRC; the disease is Venous thrombosis.