It is now established that, aside from functional loss of p53, mutant p53 GOF contributes extensively to promoting immune and inflammatory hallmarks of cancer by (1) responding to and fuelling inflammatory signalling in the TME, (2) shaping the tumour milieu to facilitate cancer progression, (3) disrupting innate tumour immunity, (4) modulating the activity of infiltrating immune cells, and (5) potentially impinging on post-apoptotic cell clearance (Figure 3). This evidence concerns the gene TP53 and cancer.