This hypothesis is supported by the status of STAT3 and p53 in prostate (DU145 and Tsu), breast (MDA-MB-468 and SK-BR-3) and ovarian (MDAH 2774, SKOV-3 and Caov-3) cancer cell lines, which express constitutively active STAT3 and either express mutant p53 or are p53 null [56]. Here, STAT3 is linked to cancer.