Through sustained NF-κB and STAT3 signalling, the impairment of the epithelial barrier, and transcriptional activation of CXCL17, the loss of wt p53 activity can increase macrophage, neutrophil, monocyte and CD4+ T cell infiltration, while limiting the infiltration of potent anti-cancer CD8+ T cells (Figure 2B) [124,125,126,127,128]. The gene discussed is TP53; the disease is cancer.