While overshadowed by the role of p53 in tumour suppression, local immune regulation has long been linked to p53 dysfunction, with viral infections such as Simian virus 40 (SV40), where Large T antigen complexes with and inactivates p53, or Human Papilloma Virus (HPV), where the viral E6 proteins mediates p53 proteasomal destruction [6,7,8], showing reduced immune responses. The gene discussed is TP53; the disease is neoplasm.