In our previous study, the expression of downstream signal transduction after stimulation with the TLR7 ligand was confirmed in the salivary glands of patients with SS and in an in vitro investigation using cultured epithelial cells obtained from SS patients [8], and pDCs appeared to be a source of type I IFN (including IFN-α and IFN-β). The gene discussed is TLR7; the disease is synovial sarcoma.