WNK2 and neurodegenerative disease: In previous studies on degenerative diseases, indeed, an involvement of mitochondrial fission was observed in the production of mitochondrial ROS in activated microglial cells, influencing the expression of pro-inflammatory mediators through the activation of factor nuclear kappa B (NF-κb) and mitogen-activated protein kinase (MAPK), representing a new therapeutic approach for preventing neurodegenerative diseases [73,93].