AR and Familial prostate cancer: Despite the present work, the detailed mechanism of action of BBR on ARpolyQ has not been clarified, a protein-specific activity of BBR on AR might be involved, since, in prostate cancer, BBR was shown to disrupt the interaction between AR and HSP90, the chaperone involved in folding and degradation of AR [81], and protective in SBMA models [82,83,84,85,86].