GRM5 and neuropathic pain: In neuropathic pain models, metabotropic glutamate receptors mGluR5 and mGluR7 are upregulated in PrL, and pharmacological interventions suggest opposing roles of these two receptors: while mGluR5 aggravates comorbid pain and negative symptoms, mGluR7 improves cognitive performance and restores excitation/inhibition balance at PrL neurons [219,220].