Nonetheless, the disease complications, if present, need some additional management, including allopurinol in patients who develop hyperuricemia, ACE-inhibitors in patients with blood hypertension, 5-ASA in GSD Ib patients who develop inflammatory bowel disease (IBD), G-CSF in GSD Ib patients with neutropenia, and hypolipemic agents in patients with hyperlipidemia. This evidence concerns the gene CSF3 and inflammatory bowel disease.