CCNA2 and melanoma: Assessing the impact of PIC-E on cell cycle phases revealed the accumulation of cells in the G2-M phase and increased cell fraction in the sub-G1 phase; these data are supported from a previous report [33] on PIC that highlighted the ability of PIC to cause SK-Mel-28 melanoma cell arrest in the G2-M phase, an effect attributed to cyclins A, E, and B1 downregulation.