Accordingly, our objectives were to determine in lung tumors and non-tumor specimens of LC patients, with and without COPD, the following parameters: (1) counts of Treg and NK cells, (2) numbers of both IgG- and IGA-secreting plasma cells, and (3) levels of the cytokines IL-10 and interferon-gamma. This evidence concerns the gene IFNG and laryngotracheoesophageal cleft.