AIC, also known as AIH-cholestatic overlap syndrome, is typically defined by the coexistence of AIH and a cholestatic syndrome that does not meet criteria for either classic PBC or PSC: alkaline phosphatase (AP) and γ-glutamyltransferase (GGT) are elevated and liver biopsy shows bile duct injury (in various histologic patterns), but anti-mitochondrial antibodies (AMA) are absent and cholangiography is normal [1]. The gene discussed is DHCR7-DT; the disease is autoimmune hepatitis.