TP53 and myelodysplastic syndrome: Three (1.2%) high-risk MDS cases (two RAEB-1, with 6% and 8% of BM blasts, respectively, and one RAEB-2, with 12% of BM blasts) displayed chromothripsis and all carried TP53 mutations, underlining the association between TP53 gene alteration and chromosomal abnormalities, and chromothripsis [39] (Figure 1D).