In the MCF7 cells, a cellular model of luminal A breast cancer in which upregulation of GRK2 and HuR frequently concur, GRK2 increased the total and basal cytosolic HuR protein levels, which correlated with a higher nuclear distribution of HIF-1α and enhanced secretion of the lymphoangiogenic factor VEGF-C in normoxic conditions. This evidence concerns the gene HIF1A and breast cancer.