Of note, the secretion of VEGF-C, a potent inducer of lymphatic vessels through which breast cancer cells often disseminate [46,47] was strongly increased in the MCF7 cells overexpressing GRK2 as compared to the parental cells, and conversely secretion was reduced upon GRK2 downregulation (Figure 5E). The gene discussed is GRK2; the disease is breast carcinoma.