Moreover, chronic adrenergic stimulation fosters the HuR/HIF1-α module in MCF7 cells through GRK2 (Figure 7), which could facilitate survival of malignant cells even before the expanding tumor mass become hypoxic, and could also improve the adaptation of tumor cells to the hypoxic environment of lymphatic vessels and to other tumor-related stresses. The gene discussed is HIF1A; the disease is neoplasm.