WNK2 and neoplasm: This activates signal transduction to the cytoplasm and then to the nucleus, through the mitogen-activated protein kinase (MAPK) rat sarcoma (RAS)/rapidly accelerated fibrosarcoma proto-oncogene serine/threonine protein kinase (RAF)/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, which ultimately promotes tumor growth and progression [7].