In the prospective stratified, biologically enriched phase II “seconD-line folfiri/aflIbercept in proSpecTIvely stratified, anti-EGFR resistaNt, metastatic coloreCTal cancer patIents with RAS Validated wild typE status” DISTINCTIVE study, RAS wt mCRC patients progressing after first-line treatment with oxaliplatin, fluoropyrimidines, and anti-EGFR mAbs receive second-line FOLFIRI–aflibercept and are prospectively allocated to either of two groups according to circulating VEGFR-2 levels at baseline [62]. The gene discussed is EGFR; the disease is cancer.