The “LY3200882 and Capecitabine in Advanced Resistant TGF-beta Activated Colorectal Cancer - European Organisation for the Research and Treatment of Cancer 1615” EORTC1615 MoTriColor (Molecularly guided Trials with specific treatment strategies in patients with advanced newly molecular defined subtypes of Colorectal cancer) trial is a phase I/II study evaluating galunisertib (LY2157299), a small oral antagonist of the TGF-β receptor type 1 (TGFβRI) kinase domain, in combination with capecitabine in refractory mCRC patients with activated TGF-β signature (NCT03470350). This evidence concerns the gene TGFB1 and colorectal cancer.