Due to the unique features of γδ T cells, such as the not MHC-restriction for tumor cell recognition and quickly production of abundant cytokines and potent cytotoxicity in response to malignancies, the anti-tumor effects of γδ T cells have demonstrated unique superiority, and γδ T cell-based cancer immunotherapy has great promise in tumor therapy [12,13]. This evidence concerns the gene HLA-C and neoplasm.