In mice, complete loss of TBK1 leads to embryonic death at approximately embryonic day 14.5 [19], whereas loss of one TBK1 allele has biphasic effects in mice that harbor the ALS-linked superoxide dismutase 1 (SOD1)-G93A mutation, accelerating the disease onset in the early stage but reducing microglial neuroinflammation and slowing disease progression at a later stage [19]. The gene discussed is TBK1; the disease is amyotrophic lateral sclerosis.