TBK1 was recently reported to phosphorylate and promote autophagy by interacting with the autophagy receptors OPTN [6,24] and SQSTM1/p62 [25,26], both of which were reported to be involved in the pathogenesis of ALS/FTD by impairing autophagy [27]. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.