OLFML3 and neoplasm: As OLFML3 is endothelial and microglia cell receptor [38], lack of its expression in PN underlined poorly developed vasculature and lack of immune cell infiltration of hypoxic tumor zone with autophagy program turned on, as the recruitment of immune-suppressive microglia into CT zone constitute a formidable barrier for lymphocytes thereby preventing their infiltration into the zone.