As for the function of TSLP in NASH, we detected the above indicators and found that ALT and AST were secreted less, the fatty degeneration degree and fibrosis degree of liver tissue were attenuated and fibrosis-related gene expression were downregulated in the NASH mice treated with AAV/sh-TSLP compared with NC group. The gene discussed is TSLP; the disease is metabolic dysfunction-associated steatohepatitis.