To investigate whether miR-142-5p inhibit NASH fibrosis through JAK-STAT signaling pathway or TSLP, we detected the TGF-β and collagen-1α2 expression in miR-142-5p-colivelin group and miR-142-5p-TSLP group. The gene discussed is SOAT1; the disease is metabolic dysfunction-associated steatohepatitis.