Similarly, from the results, the therapeutic effect on NASH was significantly reduced by down-regulating the expression of TSLP. In the validation of the expression of JAK-STAT signaling pathway, we can see that when the expression level of miR-142-5p is increased, the expression of TSLP is decreased, and the expression of phosphorylated protein is decreased when the total protein expression is unchanged, thereby the activity of the JAK-STAT signaling pathway is inhibited. The gene discussed is TSLP; the disease is metabolic dysfunction-associated steatohepatitis.