However, although 70% maximal inhibition of rat AQP4 and 20% maximal inhibition of mouse and human AQP4 have been reported in water transport assays, AER-270 had the same effect on water content in rat and mouse stroke models, suggesting that the effect is not AQP4 dependent (Farr et al., 2019). This evidence concerns the gene AQP4 and Stroke.