ADRB2 and Infertility: The revealed changes in expression of β2-AR, transcription factors, signature cytokine production dynamics of Th1 and Th2 subsets may indicate CIS treatment leads to the imbalance between Th1 and Th2 type cells, which could be one of the major causes of the development of pathology and infertility associated with chlamydia genital infection [50].