If the network is provided with evidence from patient findings, the probability distributions are automatically updated; e.g., if information about preoperative tumor grade (grade 2), L1CAM-expression (positive), cervical cytology (atypical endometrial cells present), and cancer antigen 125 (Ca-125) level (elevated) is added, the probability of having LNM increases from 8.6% to 77.7% (Fig 2B). This evidence concerns the gene MUC16 and neoplasm.