ESR1 and thrombocytosis disease: To investigate the impact of different predictors, sensitivity analyses were performed, including only clinical and histological biomarkers (Ca-125, lymphadenopathy on imaging, cervical cytology, thrombocytosis, and preoperative tumor grade) and molecular and histological biomarkers (ER, PR, L1CAM, p53, and preoperative tumor grade), showing negative impact on discrimination metrics (S4 Table).