In contrast, two miRNAs downregulated in ESCC function as tumor suppressors; miR-302b represses the expression of erb-b2 receptor tyrosine kinase 4 (ErbB4) whereas miR-134 downregulates PLXNA1 and blocks the mitogen-activated protein kinase (MAPK) signaling pathway [7, 8]. The gene discussed is ERBB4; the disease is esophageal squamous cell carcinoma.