NAC1 mediates a plethora of biological functions [3–6] and has multifaceted roles in ovarian cancer pathogenesis and progression, including promotion of cell survival, proliferation and motility [2, 7–9], prevention of cell senescence [10], activation of autophagy [11], and acquisition of a chemoresistant phenotype [2, 8, 11–13]. This evidence concerns the gene NACC1 and ovarian cancer.