Likewise, ABI1, an adaptor protein involved in cell migration, along with its downstream effector phospho-Akt (p-Akt), has been implicated in the spread of breast cancer [18]; is positively correlated with reduced H3K27me3K36me3 (p-val <7.02e-05) when inhibited by CDK inhibitor flavopiridol. This evidence concerns the gene AKT1 and breast carcinoma.