Although multiple studies in which a markedly higher rate of TP53 mutations was detected in young women, as well as medullar carcinoma, suggesting an involvement of TP53 mutations into the hereditary cancer,25, 26, 27, 28, 29 the data of GDPH and METABRIC did not indicate that age was an independent factor of TP53 mutations (P > 0.05). The gene discussed is TP53; the disease is hereditary cancer.