DDX54 and Neurodevelopmental delay: To briefly mention a few such examples, Next-Generation sequencing studies in children affected by NDD/ID identified several additional underlying RNA helicase genes including DDX59, DHX16, DHX34, DHX37 and DDX54, further implicating the role of this gene family in neuronal development and function, though the molecular processes impacted by their variants have not been characterized [93,94].