As a result, RIIAD1 was more accessible in promoter and enhancer region (marked by enriched H3K27ac ChIP-seq reads) that enriched with CpGs, i.e. CGI, in MDA-MB-231 cell lines than that in MCF-7 cell lines as shown in Figure 6, which was consistent with its elevated expression in tumor samples. The gene discussed is RIIAD1; the disease is neoplasm.