However, there was no association with axonal degeneration, monoclonal IgM gammopathy or with positivity of autoAbs to MAG as reported earlier.53,55–57 Conversely, in neuropathy patients with IgM gammopathy with late onset and sensory damage, elevated titres of IgM to sulphatide were often associated with a concomitant reactivity to MAG.56 Of note, the so called anti-MAG neuropathy syndrome was the first autoimmune neuropathy in which the target specificity was reported in humans.58 This evidence concerns the gene MAG and neuropathy.