Meanwhile, authors have investigated that PM increased the expression of amphiregulin (AREG) in human bronchial epithelial cells (HBECs) and further induced inflammation and mucus hypersecretion via the EGFR-PI3Kα-AKT/ERK pathway, which is known to promote the development and exacerbation of asthma [24]. The gene discussed is EGFR; the disease is asthma.