Similarly, Acciani et al. have investigated that the exposure of young mice to DEP exacerbated allergic responses characteristic of more severe asthma phenotypes, including the increase of Th17 effector T cells, eosinophils, and dual-positive (Th2/Th17) effector T cells, as well as increases in IgE, IL-17A, and Th2 cytokines [67]. This evidence concerns the gene IGHE and asthma.