The analysis of adaptive immunity cells revealed that despite the low levels of CD4+ T-cells and CD8+ T-cells, SCA patients exhibited a high frequency of CD4+CD69+ T-cells, CD8+CD69+ T-cells, and CD19+ B-cells regardless of the laboratorial/clinical score (Figure 3(c)). The gene discussed is CD8A; the disease is autosomal dominant cerebellar ataxia.