It was noticed that while in HD, IL-10 has several connections modulating the immune response and made an interesting triad between IL-10, IL-12, and VEGF, whereas in SCA patients, IL-10 displayed a relevant loss of connections with only a strong positive connection with IP-10 remaining, which was not observed in HD. The gene discussed is CXCL10; the disease is autosomal dominant cerebellar ataxia.