Increased levels of IL-1β, IFN-γ, IL-12, IL-17, IL-10, IL-8, IP-10, MIP-1α, and VEGF but low levels of MIP-1β were observed in SCA patients regardless of the laboratorial and clinical scores as compared to HD reference ranges. The gene discussed is CXCL8; the disease is autosomal dominant cerebellar ataxia.