Data demonstrated that SCA patients displayed an overall increase of most immunological biomarkers evaluated, include IL-1β, IL-6, IL-12, IFN-γ, IL-4, IL-17, IL-10, IL-8, IP-10, MIP-1α, MIP-1β, RANTES, VEGF, FGF-basic, and GM-CSF as compared to HD (Figures 4(a)–4(c)). This evidence concerns the gene IL10 and autosomal dominant cerebellar ataxia.