In the SCA pathophysiology, RANTES still induces the activation of the Gardos channel (Ca-dependent K+ channel) in sickle erythrocytes by an increased affinity constant for intracellular Ca+ resulting in intracellular depletion of K+ and dehydration of sickle red blood cells [88]. Here, KCNN4 is linked to autosomal dominant cerebellar ataxia.