SCA patients with high reticulocyte counts and high death risk presented a more similar network highlighted by common connections such as the TNF-α/IL-1β/MIP-1α triad, the IFN-γ/IL-13, IL-17/IL-4 triad, and the IL-4/IL-2 axes. The gene discussed is IFNG; the disease is autosomal dominant cerebellar ataxia.