Furthermore, specific biomarkers were selectively identified in the ascendant signatures of SCA patients with low reticulocyte counts, high platelet counts, and high death risk, including CD8+CD11b+, CD11b+NEU, CD8+CD49d+, and TLR2MON, respectively (Figure 6(b)). Here, ITGA4 is linked to autosomal dominant cerebellar ataxia.