TLR4 and tuberculosis: In contrast, we found that in our study population, the minor allele G in TLR4 (299G) and the minor allele T in TLR4 (399I) were less frequent in patients than in controls, and thus, these polymorphisms were significantly associated with decreased susceptibility to TB (Table 2; TLR4 299G OR = 0.31, p = 0.01; TLR4 399I OR = 0.29, p = 0.03).