Clinical studies at several different institutions have used CD19 CAR-T cell therapy in children and adults with recurrent B cell acute lymphoblastic leukemia (B-ALL), B cell non-Hodgkin's lymphoma (B-NHL), and chronic lymphocytic leukemia (CLL), and these studies showed high antitumor treatment efficacy [77, 78]. This evidence concerns the gene CD19 and B-cell chronic lymphocytic leukemia.