APOA1 and neoplasm: In the following sections, we provide an overview of HDL structure, composition, formation and function and then discuss recent findings demonstrating direct cardioprotective effects of HDL and/or its precursor, ApoA1 against DOX-induced cardiotoxicity, advances in the use of HDL based nanospheres for encapsulation of DOX for therapeutic delivery and direct anti-tumor effects of ApoA1.