For example, in the case of treatment with ApoA1 along with chemotherapeutic agents such as DOX, the ApoA1 may be acting by seeding the formation of new HDL particles which may incorporate the chemotherapeutic agent, act as targeted delivery systems for certain types of tumors, directly attenuate tumor growth, and directly induce survival signaling in cardiomyocytes, thus inducing both direct and indirect mechanisms of cardioprotection simultaneously. The gene discussed is APOA1; the disease is neoplasm.