APOA1 and neoplasm: These include understanding the mechanisms by which HDL induces cytoprotective responses in cells including cardiomyocytes, the ability of HDL and synthetic particles based on it to encapsulate DOX and serve as delivery vehicles, and findings that therapeutic treatment with HDL's major structural protein, apolipoprotein A1 (ApoA1) appears to have direct antineoplastic effects in preclinical tumor models (32–34).