Whole-genome sequence studies classify gastric adenocarcinoma (GAC) into four different subtypes: (i) Epstein-Barr virus (EBV) positive tumors, characterized by PD-L1/-L2 amplification, (ii) microsatellite unstable (MSI) cancers, (iii) tumors with chromosomal instability, and (iiii) genomically stable tumors (22). The gene discussed is CD274; the disease is cancer.