Previous studies have demonstrated that IL-17 produced by infiltrating immune cells is necessary for initiation and progression of PanIN (McAllister et al., 2014) and that IL-10 secreted by γδ Treg cells diminished the cytotoxic activity of CD8+ T cells and NK cells, resulting in tumor growth (Seo et al., 1998). This evidence concerns the gene CD8A and neoplasm.