Indeed, preclinical evidence indicated that a “sensitizer” background (specifically oncogenic Kras activation) is a necessary prerequisite when trying to identify factors (genetic or non-genetic) that accelerate progression of pancreatic cancer in mouse models (Perez-Mancera et al., 2012) where genes’ inactivation due to sleeping beauty transpositions was not sufficient to drive tumor formation in the absence of Kras activation. Here, KRAS is linked to pancreatic neoplasm.