Necroptosis can be induced by activation of the TNFR family of receptors (TNFR1, Fas, TRAILR) (Laster et al., 1988; Holler et al., 2000), TLR3 and TLR4 (He et al., 2011; Kaiser et al., 2013), interferon receptors (IFNRs) (Robinson et al., 2012) and pathogen infection (Nailwal and Chan, 2019). The gene discussed is TNFRSF1A; the disease is infection.