More generally, this property of cholesterol to modulate the mode of action of tetraspanins not only affects protein transport [e.g., CD81:CD19 (Zimmerman et al., 2016); CD9:MHCII (Silvie et al., 2003; Rocha-Perugini et al., 2009; Banse et al., 2018)], but also malaria or cytomegalovirus infection [through CD81 (Silvie et al., 2003; Rocha-Perugini et al., 2009; Banse et al., 2018)], and cell migration as described later. The gene discussed is CD81; the disease is cytomegalovirus infection.