A study indicated that NAMPT enzymatic activity enhancer P7C3 could have a neuroprotective effect in a mouse model of amyotrophic lateral sclerosis (ALS) (Tesla et al., 2012), and the levels of iNAMPT in ALS patients were lower than those of age-matched controls (Wang et al., 2017). This evidence concerns the gene NAMPT and amyotrophic lateral sclerosis.