To gain insights into the cause-and-effect relationship from 3′US-mediated HK gene repression to tumorigenesis, we revisited a previous study (Masamha et al., 2014; Park et al., 2018b) in which 3′US-ceRNA effect promotes tumorigenesis in NUDT21 knockdown (KD) in HeLa cells and glioblastoma [data available in GSE42420 (Hammond et al., 2010) and GSE78198 (Ala et al., 2013)]. Here, NUDT21 is linked to glioblastoma.