TNF and Granuloma: Recently, we showed that etanercept (a fusion protein of IgG1 Fc domain and the extracellular ligand-binding portion of the human p75 TNF receptor) slightly delayed the formation of granulomas and reduced the generation of MGCs by inhibiting cell fusion in the same way as adalimumab treatment (a human monoclonal anti-TNF-α IgG1) (Mezouar et al., 2019).