CD34 and disease arising from reactivation of latent virus: We and others have shown deletion of the entire US28 ORF from TB40/E (Humby and O'Connor, 2015; Krishna et al., 2019), Titan (Krishna et al., 2017), and FIX (Wu and Miller, 2016) strains of HCMV results in the failure to establish/maintain latent infection of hematopoietic cells, including Kasumi-3 (Humby and O'Connor, 2015; Krishna et al., 2019) and THP-1 cell lines (Wu and Miller, 2016; Krishna et al., 2017, 2019), as well as primary monocytes (Krishna et al., 2017) and cord blood-derived CD34+ HPCs (Krishna et al., 2019).