MCOLN1 and cancer: At the end of 2018, Faris and colleagues published an article in Cancers entitled “Endolysosomal Ca2+ signaling and cancer hallmark: two pore channels on the move and TRPML1 lags behind!” emphasizing the emerging role of two pore channels (TPC) in cancer, in contrast to that of comparable transient receptor potential mucolipin channel 1 (TRPML1) the role of which in cancer was still obscure (1).