With the exception of LNβ1 and glypican 1-3, 5, all the other basement membrane proteins found in RCC, e.g., LNα1, γ1, β2, Col IV, entactin, syndecan, glypican 4, and 6 and perlecan, are good prognostic factors for ccRCC but bad prognostic factors for pRCC. The gene discussed is GPC4; the disease is renal cell carcinoma.