MYC and cancer: By applying this tool to the CRISPR library, we screened molecules that increase the expression of endogenous MYC. According to previous reports, by introducing the CRISPR library into a malignant tumor cell line and carrying out selection with a drug, molecules that cause susceptibility or resistance to that drug can be identified (Konermann et al., 2015; Gilbert et al., 2014; Kampmann, 2018; Kurata et al., 2018a; Kurata et al., 2018b; Shalem et al., 2014; Wang et al., 2014; Koike-Yusa et al., 2014; Doench et al., 2016; Jain et al., 2016).