Although our study showed a similar biomarker role of plasma choline in SCF, there were some differences between our study and Danne's study: (1) there were different inclusion criteria, and compared with their 342 patients with ACS in the United States, we included 65 Chinese patients with acute or chronic chest pain and ischemia evidence; (2) Danne detected the plasma concentration in whole blood instead of plasma; and (3) their cut-off value was 28.2 μmol/L, while our cut-off value was 1030 ng/ml. The gene discussed is KITLG; the disease is ischemia.