In the five patients who died in the ICU, case 11 had lethal neonatal CPT II deficiency; case 12 carried a FOXC2 mutation, with severe clinical symptoms, and died within 72 h; case 14 had a CYBB mutation and died due to BCG vaccine-induced infection before the return of the TES results; case 28, a boy obtained in vitro fertilization, had lethal type III congenital disorder of glycosylation with COG6 mutation, whose parents insisted to keep him in ICU until death at 72 days; and case 32 with compound heterozygous mutation of IFNGR1 gene, who failed HSCT and died after two months. The gene discussed is IFNGR1; the disease is infection.