ROS production is involved in two faces of the cancer environment: in basal levels, these species are involved in PI3K/Akt-mediated cell survival and proliferation, or when excessive intracellular ROS accumulation occurs, these are involved in the cleavage of caspase-3 and caspase-7 also damaging nucleic acid bases and other compounds [4]. Here, CASP3 is linked to cancer.