One has shown that SIRT1 is reduced in trophoblasts during the last trimester of established PE [11], another study showed that SIRT1 mRNA expression is reduced in PE placentas vs. normal pregnancy and intrauterine growth restriction (IUGR) placentas [12], and the last study showed that this protein was also reduced in Human Umbilical Endothelial Cells (HUVECs) incubated with preeclamptic serum when compared to HUVEC basal control [13]. This evidence concerns the gene SIRT1 and fetal growth restriction.