INS and diabetes mellitus: In the multivariate analysis, proximal optimization technique (OR 0.150, 95% CI 0.061–0.327, p < 0.001) and age (OR 0.959, 95% CI 0.922–0.996, p < 0.029) were associated with reduced rate of ISR , whereas MV predilatation (OR 2.643, 95% CI 1.175–6.784, p = 0.028), the history of CABG (OR 2.771, 95% CI 0.991–7.100, p = 0.040) and DM treated with insulin (OR 4.213, 95% CI 1.483–11.444, p = 0.005) were associated with higher recurrence of ISR.