After JAK2/STAT3 pathway being inhibited with HJD, the cell apoptosis, collagen deposition and immunoreactivity of macrophage in colon were significantly reduced, but the expression of Ki67 was markedly enhanced in both UC group and HJD group compare with control group. This evidence concerns the gene MKI67 and spondyloepimetaphyseal dysplasia, Handigodu type.